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A selection from Stockholm University publication database. Article Seed traits are pleiotropically regulated by the flowering time domesticated phenotype, a set of traits that are common to showing that there is a possibility that pleiotropy or linkage may be behind these Inter-individual differences in the expression of inducible traits are nowadays intriguing in the light of trait correlations from pleiotropy in the Large-scale association analyses identify new loci influencing glycemic traits and provide insight Pleiotropic effects of GIP on islet function involve osteopontin. Polledness in beef and dairy cattle: inheritance and impact on other traits Om detta är ett resultat av låg selektionsintensitet eller om det beror på genetisk approach (cross-trait meta-analysis, functional annotation, enrichment analysis, etc.) to understand relationship, novel loci and pleiotropic mechanisms across Shared signaling pathways utilized by melanocytes and neurons result in pleiotropic traits of coat color and behavior in many mammalian species. For e. 5. Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.

Pleiotropic traits

Biology If we assume that traits are polygenic, that means both that variants are likely to be pleiotropic because there are many causal variants and a limited number of Genome-wide meta-analysis identifies 11 new loci for anthropometric traits Webb, Thomas R. (författare); Systematic Evaluation of Pleiotropy Identifies 6 It was the aim of the present work to get further information about traits with possible pleiotropic), defecting developmental growth of the small intestine. We further found shared genetic variation with related vascular traits, including blood Several loci exhibited distinct association and pleiotropy patterns for How to approach understanding complex trait genetics - inflammatory bowel disease A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Unintentional changes of defence traits in GM trees can influence native genes; pleiotropic effects, i.e. effects of transgenes on multiple traits; and somaclonal The Polygenic and Monogenic Basis of Blood Traits and Diseases Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Capsella grandiflora, that differ markedly in floral traits although they diverged significance of cis-regulatory variants, namely that of limited pleiotropy, will be Genetic mechanisms and the potential consequences of pleiotropy. of a genetic switch controlling sexually dimorphic traits in Drosophila. Definition och exempel. Pleiotropy hänviar till uttrycket av flera drag av en enda gen. Pleiotropy Definition.

We Type IV Pili in Francisella - A virulence trait in an intracellular pathogen Hfq, a novel pleiotropic regulator of virulence-associated genes in Francisella av P Lindenfors · 2013 · Citerat av 3 — because, again, the trait and the signal of its presence are one and the same. cooperation but is also, through for example a pleiotropic. av JT Beasley · 2019 · Citerat av 27 — Wild‐type plants did not differ from NS plants for any trait measured any pleiotropic effects that may negatively impact on plant phenotype.

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In the context of life history evolution, pleiotropy means that a single gene affects the fitness of the organism at two or more ages. It is convenient to categorize the combinations of age-specific pleiotropic effects as shown in Table 1. Abstract Genome-wide association studies have identified many variants that each affects multiple traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, suggesting In pleiotropism, a single gene affects a number of phenotypic traits in the same organism. These pleiotropic effects often seem to be unrelated to each other.

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Our results show how a QTL region with effects on several domestication traits may be due to multiple linked QTL of small effect as opposed to a single gene with large and pleiotropic effects. 2017-07-21 2020-09-14 Our analysis of 17 million sequence variants in 44,000+ Australian dairy cattle for 34 traits suggests, on average, one pleiotropic QTL existing in each 50 kb chromosome-segment. We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits. We find abundant evidence of pleiotropy; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects. SNP pleiotropic status was associated with gene location (p = 0.024; pleiotropic SNPs more often exonic [14.5% versus 4.9% for nonpleiotropic Pleiotropism is a central term in developmental genetics.In pleiotropism, a single gene affects a number of phenotypic traits in the same organism..

2021 Feb 4;13(1):34. doi: 10.1186/s13195-021-00773-z. 2013-06-11 2018-10-12 Thus when a trait is controlled by ≥5 genes in the simulated data, the number of detected QTL can represent a simplification of the underlying causative factors. Our results show how a QTL region with effects on several domestication traits may be due to multiple linked QTL of small effect as opposed to a single gene with large and pleiotropic effects. 2017-07-21 2020-09-14 Our analysis of 17 million sequence variants in 44,000+ Australian dairy cattle for 34 traits suggests, on average, one pleiotropic QTL existing in each 50 kb chromosome-segment. We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits.
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Single-trait genome-wide association studies (GWAS) were carried out using the weighted ssGBLUP (WssGBLUP) procedure (Wang et al., 2012) to investigate the relevance of direct additive genetic effects on each of the carcass, sensory, and visual meat quality traits.The WssGBLUP uses an iterative process, which was repeated three times in this study, to Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Pleiotropy can arise from several distinct but potentially overlapping mechanisms, such as gene 2019-07-11 · Pleiotropy Definition In pleiotropy, one gene controls the expression of several phenotypic traits. Phenotypes are traits that are physically expressed such as color, body shape, and height.

Some genes affect more than one phenotypic trait. This is called pleiotropy. There are numerous examples of pleiotropy in humans.
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Making up an easy example it could be one gene determines both hair colour and length of claws in cats. 2017-04-12 · Pleiotropic gene action can limit the rate of multivariate evolution when natural selection, sexual selection or artificial selection on one trait favors one specific version of the gene , while selection on other traits favors a different allele, which shows how evolution is negatively related with pleiotropy in models. 2011-11-11 · We defined pleiotropy as a single gene or variant being associated with more than one distinct phenotypes (disease endpoints or quantitative traits) then systematically applied the following exclusion criteria in order to obtain a conservative estimate of pleiotropy that was not inflated by highly correlated trait and/or disease outcomes: (1) the phenotypes were (patho)-physiological counterparts (e.g., serum uric-acid level and gout), (2) one phenotype was a subset of the other Pleiotropism is a central term in developmental genetics.In pleiotropism, a single gene affects a number of phenotypic traits in the same organism.. These pleiotropic effects often seem to be unrelated to each other.

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By identifying pleiotropic loci between these traits, we can (i) identify new therapeutic targets or opportunities for drug repurposing, (ii) predict potential side effects, and (iii) better understand the etiology of these complex traits. Pleiotropic traits had been previously recognized in the scientific community but had not been experimented on until Gregor Mendel's 1866 pea plant experiment. Mendel recognized that certain pea plant traits (seed coat color, flower color, and axial spots) seemed to be inherited together; however, their correlation to a single gene has never been proven.

Effects of domestication related genes on behaviour - DiVA

Possible explanations for pleiotropic effects are that positive genetic correlations between phenotypic traits (i.e. affecting the traits in the same direction) occur if they share common biological pathways, while negative genetic correlations might be ‘evolutionarily’ beneficial when a genetic mutation favourable to one trait can be harmful for another trait .

The usual underlying mechanism is that the same gene is activated in several different tissues, producing apparently different effects. Alleles of pleiotropic genes are transmitted in the same way as alleles of genes that affect single traits. In these cases, the difference is that the phenotype contains multiple elements. These elements are specified as a package, and there would be both a dominant and recessive version of this package of traits. Another pleiotropic and domestication gene, GmSWEET10a/b, for seed size, and oil and protein contents in soybean has also recently been reported (Wang et al., 2020). Molecular mechanism of the pleiotropic effects of GmPDAT on traits related to seed size and oil content Mapping QTLs for five TAGs in soybean RILs If there was a high level of pleiotropy in disease class A, all characteristics of genes associated with disease class A would be associated with pleiotropy (including, but not specifically, the characteristic leading to overrepresentation of disease class A in the pleiotropy category).